解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The gene encoding MG Orn has been identified from a metagenomic library created from the intertidal zone in Svalbard and encodes a protein of 184 amino acid residues. The mg orn gene has been cloned, recombinantly expressed in Escherichia coli, and purified to homogeneity. Biochemical characterization of the enzyme sh...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12720
更新日期:2019-10-01 00:00:00
abstract::Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is an important enzyme in phospholipid remodeling, a process that influences the biophysical properties of cell membranes and thus cell function. Multiple lines of evidence suggest that LPCAT3 is involved in several diseases, including atherosclerosis, non-alcoholic s...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12712
更新日期:2019-10-01 00:00:00
abstract::The Masculinizer (Masc) gene encodes a CCCH-tandem zinc finger protein that controls both masculinization and dosage compensation in the silkworm Bombyx mori. We previously measured the masculinizing activity of the lepidopteran Masc proteins using B. mori ovary-derived cell line BmN-4. Here, we established an RNA-seq...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12698
更新日期:2019-09-01 00:00:00
abstract::Inorganic polyphosphate (polyP) is a linear polymer containing tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. PolyP promotes osteocalcification and bone mineralization in both mouse and human osteoblastic cells. In the present study, we examined the molecular mechanism by whi...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12703
更新日期:2019-09-01 00:00:00
abstract::The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, we downloaded microarray datasets of PD from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PD...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12687
更新日期:2019-08-01 00:00:00
abstract::The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase-based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contains seven Apoptotic ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12646
更新日期:2019-07-01 00:00:00
abstract::Metastasis is the primary contributor to colorectal cancer mortality. High-intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy that exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. However, it remains unclear whether HIFU can influence t...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12642
更新日期:2019-06-01 00:00:00
abstract::Abdominal arterial aneurysm (AAA) shares many features with autoimmune diseases and appears to be a T-cell-mediated process. In addition, certain epigenetic changes, including DNA methylation, are associated with AAA. In this study, we investigated epigenetic modifications in regulatory T cells (Tregs) from AAA patien...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12643
更新日期:2019-06-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative a...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12648
更新日期:2019-06-01 00:00:00
abstract::Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy as well as in improved efficacy of conventional antica...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12628
更新日期:2019-05-01 00:00:00
abstract::Fibroblast growth factor 11 (FGF11) is a member of the intracellular fibroblast growth factor superfamily. Here, we identified FGF11 as a novel mediator of adipogenesis. During 3T3-L1 adipocyte differentiation, the expression of FGF11 decreased at the mitotic clonal expansion stage and increased at the terminal differ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12619
更新日期:2019-03-12 00:00:00
abstract::Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy-associated long non-coding RNA (lncRNA) in glioma patients. In...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12601
更新日期:2019-03-05 00:00:00
abstract::The base excision repair pathway plays an important role in correcting damage induced by either physiological or external effects. This repair pathway removes incorrect bases from the DNA. The uracil base is among the most frequently occurring erroneous bases in DNA, and is cut out from the phosphodiester backbone via...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12567
更新日期:2019-02-09 00:00:00
abstract::Osteosarcoma is the most common primary solid malignancy of the bone, and its high mortality usually correlates with early metastasis. In this study, we developed a risk score model to help predict metastasis at the time of diagnosis. We downloaded and mined four expression profile datasets associated with osteosarcom...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12592
更新日期:2019-02-02 00:00:00
abstract::Lactobionic acid (O-β-galactosyl-(1-4)-gluconic acid) (LBA) is a high-value lactose derivative, produced via oxidation of the reducing terminal of lactose. LBA can be produced by fermentation using certain microorganisms, although subsequent purification is challenging. Therefore, we have attempted to identify an enzy...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12582
更新日期:2019-01-16 00:00:00
abstract::An imbalance of branched-chain amino acids (BCAAs) in the brain may result in neuropathological conditions, such as autism spectrum disorders. The L-type amino acid transporter 1 (LAT1), encoded by the solute carrier transporter 7a5 (Slc7a5) gene, is critical for maintaining normal levels of BCAAs in the brain. Howeve...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12559
更新日期:2019-01-07 00:00:00
abstract::Cell wall mannan of the pathogenic yeast Candida krusei was prepared using the antibiotic Benanomicin A, which has a lectin-like function. The chemical structure of this molecule was found to be similar to that of mannan prepared from the same yeast by the conventional method using Fehling reagent. Only a few degradat...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12558
更新日期:2018-12-10 00:00:00
abstract::Soft cheese with white rind lacks essential fatty acids (EFAs), and as a result its long-term consumption may lead to various kinds of cardiovascular and cerebrovascular diseases, such as hyperlipidemia, hypertension, and atherosclerosis. Geotrichum candidum is a dimorphic yeast that plays an important role in the rip...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12553
更新日期:2018-12-06 00:00:00
abstract::Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-β-barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is still unknown. We report the first evidence of the heme-Fe(III)-bas...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12534
更新日期:2018-11-09 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease with increased risk of cardiovascular events and mortality that can be attributed to accelerated atherosclerosis. This pilot study aimed to investigate if changes in blood parameters were compatible with atherosclerotic events in RA patients. To this aim, 45 ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12531
更新日期:2018-11-06 00:00:00
abstract::Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down-regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH-7. TXNIP contains putative phosphorylation sites, but the effe...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12518
更新日期:2018-10-01 00:00:00
abstract::We previously reported a profound augmentation in the hepatic levels of a pro-inflammatory precursor, arachidonic acid (AA), during liver tumorigenesis. Here, we report a critical role of the induced reactive oxygen species (ROS)-mediated cellular activation of a protein cross-linking enzyme, transglutaminase 2 (TG2),...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12511
更新日期:2018-09-11 00:00:00
abstract::Receptor activator of nuclear factor-κB ligand (RANKL) is required for initiation of osteoclastogenesis, with the signaling pathway including the NF-kB, c-Fos, and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) transcription factors. Because NFATc1 expression is autoamplified, we investigated the molecula...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12513
更新日期:2018-09-10 00:00:00
abstract::The expression of death receptor 6 (DR6) is abnormal in some cancer types, but the function and underlying molecular mechanisms of DR6 in tumor progression are not yet clear. In the present study, our analysis of ovarian cancer RNA sequencing data from The Cancer Genome Atlas revealed that DR6 is upregulated in human ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12492
更新日期:2018-08-07 00:00:00
abstract::DNA damage-inducible 1 (Ddi1) is a multidomain protein with one of the domains being retropepsin-like. HIV-1 protease inhibitors were found to reduce opportunistic infections caused by pathogens like Leishmania and Plasmodium, and some of them were shown to inhibit the growth of these parasites. In Leishmania, Ddi1 wa...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12491
更新日期:2018-08-03 00:00:00
abstract::The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy-rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12461
更新日期:2018-07-04 00:00:00
abstract::Despite progress in the treatment of hepatocellular carcinoma (HCC), 5-year survival rates remain low. Thus, a more comprehensive approach to explore the mechanism of HCC is needed to provide new leads for targeted therapy. We performed an integrated analysis to discover the relationship between DNA methylation and ge...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12433
更新日期:2018-05-30 00:00:00
abstract::Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12441
更新日期:2018-05-21 00:00:00
abstract::Sorafenib is an inhibitor of a variety of tyrosine kinase receptors used to treat various cancers including hepatocellular, renal cell and thyroid carcinoma. It has been shown to change various targets associated with osteosarcoma, but the detailed mechanism remains unclear. In order to identify key genes, enriched pa...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12428
更新日期:2018-04-24 00:00:00
abstract::Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expre...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12423
更新日期:2018-04-19 00:00:00
abstract::IL-1 family cytokines act as apical initiators of inflammation in many settings and can promote the production of a battery of inflammatory cytokines, chemokines and other inflammatory mediators in diverse cell types. IL-36α, IL-36β and IL-36γ, which belong to the extended IL-1 family, have been implicated as key init...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12406
更新日期:2018-03-25 00:00:00
abstract::Dihydroorotate dehydrogenase (DHODH) is a flavin-binding enzyme essential for pyrimidine biosynthesis, which converts dihydroorotate to orotate. Three-dimensional structures of cytosolic DHODH of parasitic protozoa are of interest in drug discovery for neglected tropical diseases, especially because these enzymes poss...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12403
更新日期:2018-03-06 00:00:00
abstract::Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape and regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect of four tropomyosin isoforms on gene e...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12386
更新日期:2018-02-19 00:00:00
abstract::Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by wester...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12383
更新日期:2018-01-31 00:00:00
abstract::Ki-67 (MKI67) is a marker of cellular proliferation of cancer. Here, we show that Ki-67 is post-transcriptionally regulated through alternative polyadenylation (APA) and microRNAs in breast cancer. We show that shortening of the Ki-67 3'UTR results in the loss of the binding sites for the suppressive miRNAs and thus r...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12364
更新日期:2018-01-26 00:00:00
abstract::Curcumin is a polyphenolic phytonutrient that has antineurodegenerative properties. In this study, we investigated the anti-amyloidogenic properties of curcumin. Following incubation with curcumin, intrinsic tryptophan fluorescence emission of apolipoprotein (apo) A-I was strongly quenched. At the same time, curcumin ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12372
更新日期:2018-01-10 00:00:00
abstract::miR-193a-3p is a tumor-related miRNA playing an essential role in tumorigenesis and progression of non-small cell lung cancer (NSCLC). The objective of the present study was to investigate the relationship between miR-193a-3p expression and clinical value and to further explore the potential signaling of miR-193a-3p i...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12354
更新日期:2018-01-04 00:00:00
abstract::Photodynamic therapy is an advanced method of treating cancer and various benign diseases, including infections. It uses light-activated molecules [photosensitizers (PSs)] to generate reactive oxygen species (ROS) when irradiated with light of a specific wavelength. This study examined the photophysical and photosensi...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12359
更新日期:2018-01-02 00:00:00
abstract::Flavin adenine dinucleotide (FAD), synthesized from riboflavin, is redox cofactor in energy production and plays an important role in cell survival. More recently, riboflavin deficiency has been linked to developmental disorders, but its role in stem cell differentiation remains unclear. Here, we show that FAD treatme...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12331
更新日期:2017-10-17 00:00:00
abstract::Inovirus XacF1 (7325 nucleotides) is integrated into the genome of Xanthomonas citri pv. citri (Xcc) strains at the host dif site (attB) by the host XerC/D recombination system. The XacF1 attP sequence is located within the coding region of ORF12, a possible phage regulator. After integration, this open reading frame ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1002/2211-5463.12312
更新日期:2017-09-19 00:00:00